Back to Search Start Over

The p51 subunit of human immunodeficiency virus type 1 reverse transcriptase is essential in loading the p66 subunit on the template primer

The p51 subunit of human immunodeficiency virus type 1 reverse transcriptase is essential in loading the p66 subunit on the template primer

Authors :
Harris, Dylan
Lee, Reaching
Misra, Hari S.
Pandey, Pradeep K.
Pandey, Virendra N.
Source :
Biochemistry. April 28, 1998, Vol. 37 Issue 17, p5903, 6 p.
Publication Year :
1998

Abstract

A study was conducted to examine the possible function of the p51 subunit of HIV-1 reverse transcriptase (RT) in the template-primer binding process. The effects of acetonitrile addition on the polymerase activity of HIV-1 RT were also studied before and after the templaten primer binding step. Results indicated that acetonitrile dissociated the subunits of the HIV-1 RT into catalytically inactive monomers.

Details

ISSN :
00062960
Volume :
37
Issue :
17
Database :
Gale General OneFile
Journal :
Biochemistry
Publication Type :
Academic Journal
Accession number :
edsgcl.21010359