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Complex segmental duplications mediate a recurrent dup(X)(p11.22-p11.23) associated with mental retardation, speech delay, and EEG anomalies in males and females
- Source :
- American Journal of Human Genetics. Sept 11, 2009, Vol. 85 Issue 3, p394, 7 p.
- Publication Year :
- 2009
-
Abstract
- A whole-genome oligonucleotide-based array comparative genomic hybridization (aCGH) method is used to identify a previously undescribed syndrome characterized by recurrent duplications of Xp11.22-p11.23 chromosomes associated with mental retardation, speech delay, and EEG anomalies in males and females. Research reveals that most of the rearrangements are mediated by recombinations between adjacent complex segmental duplications.
Details
- Language :
- English
- ISSN :
- 00029297
- Volume :
- 85
- Issue :
- 3
- Database :
- Gale General OneFile
- Journal :
- American Journal of Human Genetics
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.210566638