Growth factor-induced p42/p44 MAPK nuclear translocation and retention requires both MAPK activation and neosynthesis of nuclear anchoring proteins

Research was conducted to illustrate how the nuclear translocation of p42 and p44 mitogen-activated protein kinases (MAPK) can be triggered via the activation of the p42/p44 MAPK pathway. Nuclear accumulation was observed to be facilitated by the use of the chimera Raf-1:ER to directly activate the pathway. The neosynthesis of short-lived proteins are required for the nuclear accumulation of p42/p44 MAPK.