Dynamics and energetics of the base flipping conformation studied with base pair-mimic nucleosides

Base flipping induced by the base pair analogues of deoxyadenosine and deoxycytidine derivatives tethering a phenyl or naphthyl group was explored to study the dynamics and energetics of unusual conformation observed during DNA repair and DNA and RNA modification processes. The results for the base flipping which occurred in competition with base pair formation could be applied to study the base flipping conformation under the equilibrium with base pairing.