RecA-independent DNA damage induction of Mycobacterium tuberculosis ruvC despite an appropriately located SOS box

Authors :: Dawson, Lisa F.
Dillury, Joanna
Davis, Elaine O.
Source :: Journal of Bacteriology. Jan, 2010, Vol. 192 Issue 1-2, p599, 5 p.
Publication Year :: 2010
Abstract: Mycobaeterium tuberculosis ruvC was induced by DNA damage in a ArecA strain despite having an appropriately positioned SOS box to which LexA binds in vitro. An inducible transcript start mapped within the SOS box, and transcriptional fusions identified the promoter. Disruption of the SOS box did not prevent induction, indicating that an alternative mechanism plays a significant role in the control of ruvC expression. doi: 10.1128/JB.01066-09

Subjects :: Mycobacterium tuberculosis -- Genetic aspects
Gene expression -- Research
Bacterial genetics -- Research
DNA damage -- Research
Biological sciences

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