Direct metalation of heteroaromatic esters and nitriles using a mixed lithium-cadmium base. Subsequent conversion to dipyridopyrimidinones

Authors :: Bentabed-Abadsa, Ghenia
Sidaty Cheikh Sid Ely
Hesse, Stephanie
Nassar, Ekhlass
Chevallier, Floris
Tan Tai Nguyen
Derdour, Aicha
Mongin, Florence
Source :: Journal of Organic Chemistry. Feb 5, 2010, Vol. 75 Issue 3, 839-847
Publication Year :: 2010
Abstract: Pyridine nitriles and esters are metalated at the position next to the directing group by using [(TMP).sub.3]CdLi in tetrahydrofuran. Ethyl iodopyridinecarboxylates are involved in a one-pot palladium-catalyzed cross-coupling reaction/cyclization by using 2-aminoyridine to produce new dipyridopyrimidinones.

Subjects :: Ring formation (Chemistry) -- Usage
Nitriles -- Chemical properties
Nitriles -- Structure
Palladium catalysts -- Chemical properties
Palladium catalysts -- Structure
Pyridine -- Chemical properties
Pyridine -- Structure
Tetrahydrofuran -- Chemical properties
Tetrahydrofuran -- Structure
Cadmium -- Chemical properties
Cadmium -- Structure
Biological sciences
Chemistry

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