Small molecule colorimetric probes for specific detection of human arylamine N-acetyltransferase 1, a potential breast cancer biomarker

Authors :: Laurieri, Nicola
Crawford, Matthew H.J.
Kawamura, Akane
Westwood, Isaac M.
Robinson, James
Fletcher, Ai M.
Davies, Stephen G.
Sim, Edith
Russell, Angela J.
Source :: Journal of the American Chemical Society. March 17, 2010, Vol. 132 Issue 10, 3238-3239
Publication Year :: 2010
Abstract: The identification, synthesis, and evaluation of a series of naphthoquinone derivatives as selective inhibitors of human arylamine N-acetyltransferase 1 and mouse arylamine N-acetyltransferase 2 are described. The obtained molecules might be utilized as sensors to detect the presence of human NAT1 in cell lysates.

Subjects :: Amines -- Chemical properties
Arylation -- Analysis
Enzyme inhibitors -- Structure
Enzyme inhibitors -- Chemical properties
Quinone -- Structure
Quinone -- Chemical properties
Transferases -- Chemical properties
Chemistry

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