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Piccolo and bassoon maintain synaptic vesicle clustering without directly participating in vesicle exocytosis
- Source :
- Proceedings of the National Academy of Sciences of the United States. April 6, 2010, Vol. 107 Issue 14, p6504, 6 p.
- Publication Year :
- 2010
-
Abstract
- Piccolo and bassoon are highly homologous multidomain proteins of the presynaptic cytomatrix whose function is unclear. Here, we generated piccolo knockin/knockout mice that either contain wild-type levels of mutant piccolo unable to bind [Ca.sup.2+] (knockin), ~60% decreased levels of piccolo that is C-terminally truncated (partial knockout), or active zone | neurotransmitter release | synapse | vesicle docking | synaptogenesis doi/10.1073/pnas.1002307107
Details
- Language :
- English
- ISSN :
- 00278424
- Volume :
- 107
- Issue :
- 14
- Database :
- Gale General OneFile
- Journal :
- Proceedings of the National Academy of Sciences of the United States
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.224519716