Piccolo and bassoon maintain synaptic vesicle clustering without directly participating in vesicle exocytosis

Authors :: Mukherjee, Konark
Yang, Xiaofei
Gerber, Stefan H.
Kwon, Hyung-Bae
Ho, Angela
Castillo, Pablo E.
Liu, Xinran
Sudhof, Thomas C.
Source :: Proceedings of the National Academy of Sciences of the United States. April 6, 2010, Vol. 107 Issue 14, p6504, 6 p.
Publication Year :: 2010
Abstract: Piccolo and bassoon are highly homologous multidomain proteins of the presynaptic cytomatrix whose function is unclear. Here, we generated piccolo knockin/knockout mice that either contain wild-type levels of mutant piccolo unable to bind [Ca.sup.2+] (knockin), ~60% decreased levels of piccolo that is C-terminally truncated (partial knockout), or active zone | neurotransmitter release | synapse | vesicle docking | synaptogenesis doi/10.1073/pnas.1002307107

Subjects :: Exocytosis -- Physiological aspects
Mice, mutant strains -- Research
Neurotransmitters -- Properties
Science and technology

Language :: English
ISSN :: 00278424
Volume :: 107
Issue :: 14
Database :: Gale General OneFile
Journal :: Proceedings of the National Academy of Sciences of the United States
Publication Type :: Academic Journal
Accession number :: edsgcl.224519716

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