Prodrugs forming high drug loading multifunctional nanocapsules for intracellular cancer drug delivery

A new concept directly using drug molecules to fabricate nanocarriers in order to minimize use of inert materials, substantially increase the drug loading content, and suppress premature burst release is described. The concept directly using drugs as part of a carrier could be applied to fabricate other highly efficient nanocarriers with a substantially reduced use of inert carrier materials and increased drug loading content without premature burst release.