Angiogenin induces nitric oxide synthesis in endothelial cells through PI-3 and Akt kinases

A study on relationships between the effect of angiogenin, a major angiogenic factor and extracellular nitric oxide (NO) release, a well known biological mediator involved in vascular physiology is presented. The results provide insight into the mechanism leading to NO production and the interaction of angiogenin with the cell nucleus to activate nitric oxide synthase (NOS).