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Cross-link structure affects replication-independent DNA interstrand cross-link repair in mammalian cells
- Source :
- Biochemistry. May 11, 2010, Vol. 49 Issue 18, 3977-3988
- Publication Year :
- 2010
-
Abstract
- A study was conducted to understand the cross-link structure of DNA interstrand that affects the repair in nonreplicating reporter plasmids that contain a mispaired [N.sup.4]C-ethyl-[N.sup.4]C (C-C), N3T-ethyl-N3T (T-T), or N1I-ethyl-N3T (I-T) ICL. The insertion of both, C and G residues at the C-C cross-link site without any need for Rev1 for repair indicated that replicative or other translesion polymerases could bypass the C-C remnant.
Details
- Language :
- English
- ISSN :
- 00062960
- Volume :
- 49
- Issue :
- 18
- Database :
- Gale General OneFile
- Journal :
- Biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.226779475