Carbon monoxide reduces pulmonary ischemia-reperfusion injury in miniature swine

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.jtcvs.2009.09.016 Byline: Hisashi Sahara, Akira Shimizu, Kentaro Setoyama, Masayoshi Okumi, Manei Oku, Emma Samelson-Jones, Kazuhiko Yamada Abbreviations: CO, carbon monoxide; COHb, carboxyhemoglobin; CXR, chest x-ray; HMGB1, high-mobility group box 1; IRI, ischemia-reperfusion injury; Pao.sub.2, arterial oxygen tension Abstract: Carbon monoxide is produced endogenously as a by-product of heme catalysis and has been shown to reduce ischemia-reperfusion injury in a variety of organs in murine models. The aims of this translational research were to establish an in situ porcine lung model of warm ischemia-reperfusion injury and to evaluate the cytoprotective effects of low-dose inhaled carbon monoxide in this model. Author Affiliation: Xenotransplantation Surgery Section, Frontier Science Research Center, Kagoshima University, Kagoshima, Japan Article History: Received 2 June 2009; Revised 15 August 2009; Accepted 7 September 2009 Article Note: (footnote) This research was supported by a Grant-in-Aid for Young Scientists (to H.S.) and the Kagoshima University Research Awards (to K.Y.)., Disclosures: None.