A biosynthetic pathway for BE-7585A, a 2-thiosugar-containing angucycline-type natural product

Structural analysis and genetic and biochemical experiments were performed for BE-7585A produced by Amycolatopsis orientalis subsp. vinearia BA-07585 which has a 2-thiosugar and is a member of the angucycline class of compounds. The spectroscopic analyses verified the structure of BE-7585A to be closely related to rhodonocardin A and provided insight into the biosynthetic pathway for BE-7585A which could be applied for future biochemical studies of 2-thiosugar biosynthesis and BE-7585A assembly.