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The Mohawk homeobox gene is a critical regulator of tendon differentiation
- Source :
- Proceedings of the National Academy of Sciences of the United States. June 8, 2010, Vol. 107 Issue 23, p10538, 5 p.
- Publication Year :
- 2010
-
Abstract
- Mohawk (Mkx) is a member of the Three Amino acid Loop Extension superclass of atypical homeobox genes that is expressed in developing tendons. To investigate the in vivo functions of Mkx, we generated [Mkx.sup.-/-] mice. These mice had hypoplastic tendons throughout the body. Despite the reduction in tendon mass, the cell number in tail tendon fiber bundles was similar between wild-type and [Mkx.sup.-/-] mice. We also observed small collagen fibril diameters and a down-regulation of type I collagen in [Mkx.sup.-/-] tendons. These data indicate that Mkx plays a critical role in tendon differentiation by regulating type I collagen production in tendon cells. doi/ 10.1073/pnas.1000525107
Details
- Language :
- English
- ISSN :
- 00278424
- Volume :
- 107
- Issue :
- 23
- Database :
- Gale General OneFile
- Journal :
- Proceedings of the National Academy of Sciences of the United States
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.229302071