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A practical synthesis of 5-lipoxygenase inhibitor MK-0633
- Source :
- Journal of Organic Chemistry. June 18, 2010, Vol. 75 Issue 12, 4154-4160
- Publication Year :
- 2010
-
Abstract
- A practical, chromatography-free preparation of 5-lipoxygenase inhibitor MK-0633 p-toluenesulfonate is discussed. An improved second route has featured an inexpensive diastereomeric salt resolution of vinyl hydroxyl-acid followed by a robust end-game featuring hydrazide aylation/1,3,4-oxadiazole ring closure/salt formation sequence, which has produced MK-0633 p-toluenesulfonate.
Details
- Language :
- English
- ISSN :
- 00223263
- Volume :
- 75
- Issue :
- 12
- Database :
- Gale General OneFile
- Journal :
- Journal of Organic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.231785936