Back to Search
Start Over
Bladder cancer mortality of workers exposed to aromatic amines: a 58-year follow-up
- Source :
- Journal of the National Cancer Institute. July 21, 2010, Vol. 102 Issue 14, p1096, 4 p.
- Publication Year :
- 2010
-
Abstract
- We previously investigated bladder cancer risk in a cohort of dyestuff workers who were heavily exposed to aromatic amines from 1922 through 1972. We updated the follow-up by 14 years (through 2003) for 590 exposed workers to include more than 30 years of follow-up since last exposure to aromatic amines. Expected numbers of deaths from bladder cancer and other causes were computed by use of national mortality rates from 1951 to 1980 and regional mortality rates subsequently. There were 394 deaths, compared with 262.7 expected (standardized mortality ratio = 1.50, 95% confidence interval = 1.36 to 1.66). Overall, 56 deaths from bladder cancer were observed, compared with 3.4 expected (standardized mortality ratio = 16.5, 95% confidence interval = 12.4 to 21.4). The standardized mortality ratio for bladder cancer increased with younger age at first exposure and increasing duration of exposure. Although the standardized mortality ratio for bladder cancer steadily decreased with time since exposure stopped, the absolute risk remained approximately constant at 3.5 deaths per 1600 man-years up to 29 years after exposure stopped. Excess risk was apparent 36 years or more after last exposure. J Natl Cancer Inst 2010;102:1096-1099 DOI: 10.1093/jnci/djq214
- Subjects :
- Occupational health and safety -- Health aspects
Occupational health and safety -- Research
Aromatic amines -- Health aspects
Aromatic amines -- Research
Bladder cancer -- Risk factors
Bladder cancer -- Patient outcomes
Bladder cancer -- Research
Mortality -- United States
Mortality -- Risk factors
Mortality -- Research
Health
Subjects
Details
- Language :
- English
- ISSN :
- 00278874
- Volume :
- 102
- Issue :
- 14
- Database :
- Gale General OneFile
- Journal :
- Journal of the National Cancer Institute
- Publication Type :
- Periodical
- Accession number :
- edsgcl.233825274