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The association of hemoglobin A1c with incident heart failure among people without diabetes: the atherosclerosis risk in communities study
- Source :
- Diabetes. August, 2010, Vol. 59 Issue 8, p2020, 7 p.
- Publication Year :
- 2010
-
Abstract
- OBJECTIVE--This study sought to investigate an association of HbA1c (A1C) with incident heart failure among individuals without diabetes and compare it to fasting glucose. RESEARCH DESIGN AND METHODS--We studied 11,057 participants of the Atherosclerosis Risk in Communities (ARIC) Study without heart failure or diabetes at baseline and estimated hazard ratios of incident heart failure by categories of A1C ( RESULTS--A total of 841 cases of incident heart failure hospitalization or deaths (International Classification of Disease, 9th/10th Revision, 428/I50) occurred during a median follow-up of 14.1 years (incidence rate 5.7 per 1,000 person-years). After the adjustment for covariates including fasting glucose, the hazard ratio of incident heart failure was higher in individuals with A1C 6.0-6.4% (1.40 [95% CI, 1.09-1.79]) and 5.5-6.0% (1.16 [0.98-1.37]) as compared with the reference group. Similar results were observed when adjusting for insulin level or limiting to heart failure cases without preceding coronary events or developed diabetes during follow-up. In contrast, elevated fasting glucose was not associated with heart failure after adjustment for covariates and A1C. Similar findings were observed when the top quartile (A1C, 5.7-6.4%, and fasting glucose, 108-125 mg/dl) was compared with the lowest quartile ( CONCLUSIONS--Elevated A1C (≥5.5-6.0%) was associated with incident heart failure in a middle-aged population without diabetes, suggesting that chronic hyperglycemia prior to the development of diabetes contributes to development of heart failure.<br />Diabetes is one of the most important risk factors for heart failure (1). Among people with diabetes, a dose relationship between glycemia measured by HbA1c (A1C) and heart failure risk [...]
Details
- Language :
- English
- ISSN :
- 00121797
- Volume :
- 59
- Issue :
- 8
- Database :
- Gale General OneFile
- Journal :
- Diabetes
- Publication Type :
- Periodical
- Accession number :
- edsgcl.234418799
- Full Text :
- https://doi.org/10.2337/db10-0165