Chrysophaentins A-H, antibacterial bisdiarylbutene macrocycles that inhibit the bacterial cell division protein FtsZ

Extensive 2D NMR and MS techniques were used for structural characterization of eight new antimicrobial natural products named chrysophaentins A-H belonging to a new structural class isolated from the marine chrysophyte alga Chrysophaeum taylori. Chrysophaentin A, identified as one of the most potent antibiotic, inhibited the growth of clinically relevant gram-positive bacteria including methicillin-resistant Staphylococcus aureus, multidrug-resistant S. aureus and vancomycin-resistant Enterococcus faecium.