[13.sup]CH[D.sub.2] methyl group probes of millisecond time scale exchange in proteins by [1.sup]H relaxation dispersion: an application to proteasome gating residue dynamics

The article presents a new methodology, which uses the [1.sup]H relaxation dispersion phenomenon for the quantification of the [13.sup]CH[D.sub.2] methyl group probes of millisecond time scale exchange in proteins. The application of the technique for the analysis of proteasome gating residue dynamics is also discussed.