Toward L-homo-DNA: stereoselective de novo synthesis of [beta]-L-erythro-hexopyranosyl nucleosides

A novel route is developed for 2' ,3' -dideoxy-[beta]-L-erythro-hexopyranosyl nucleosides equipped with a 1' -([N.sup.6]-benzolyadenin-9-yl) or a 1' -(thymin-1-yl) moiety. The synthesis of the enantiopure sugar moiety is performed by a de novo approach based on a domino reaction as the main step and N-glycosylation is analyzed by either nucleobase-transfer mechanism or in situ anomerization.