Streptococcal serum opacity factor increases the rate of hepatocyte uptake of human plasma high-density lipoprotein cholesterol

Tbe human hepatoma cells and lipoprotein receptor-specific Chinese hamster ovary (CHO) cells are utilized to test the hypothesis that hepatic uptake of cholesteryl ester-rich microemulsion (CERM) that contains the cholesterol esters (CE) via multiple apo E-dependent receptors would be faster than that of high-density lipoproteins (HDL)-CE. The obtained data demonstrated that serum opacity factor (SOF) treatment of HDL increased the rate of CE uptake via multiple hepatic apo E receptors.