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Asymmetric bromolactonization using amino-thiocarbamate catalyst

Authors :
Ling Zhou
Chong Kiat Tan
Xiaojian Jiang
Feng Chen
Ying-Yeung Yeung
Source :
Journal of the American Chemical Society. Nov 10, 2010, Vol. 132 Issue 44, 15474-15476
Publication Year :
2010

Abstract

A newly developed amino-thiocarbamate-catalyzed bromolactonization of unsaturated carboxylic acids is described. The newly developed protocol could be applied in the enantioselective synthesis of the key intermediates of VLA-4 antagonists.

Details

Language :
English
ISSN :
00027863
Volume :
132
Issue :
44
Database :
Gale General OneFile
Journal :
Journal of the American Chemical Society
Publication Type :
Academic Journal
Accession number :
edsgcl.244912669