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Mechanistic studies of the biosynthesis of 2-thiosugar: evidence for the formation of an enzyme-bound 2-ketohexose intermediate in BexX-catalyzed reaction
- Source :
- Journal of the American Chemical Society. Nov 10, 2010, Vol. 132 Issue 44, 15544-15546
- Publication Year :
- 2010
-
Abstract
- The first mechanistic insight into 2-thiosugar production in an angucycline-type antibiotic, BE-7585A, is reported. The results indicated that the sulfur insertion mechanism in 2-thiosugar biosynthesis shares similarities with that for thiamin biosynthesis.
Details
- Language :
- English
- ISSN :
- 00027863
- Volume :
- 132
- Issue :
- 44
- Database :
- Gale General OneFile
- Journal :
- Journal of the American Chemical Society
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.244916256