Heparanase powers a chronic inflammatory circuit that promotes colitis-associated tumorigenesis in mice

Authors :: Lerner, Immanuel
Hermano, Esther
Zcharia, Eyal
Rodkin, Dina
Bulvik, Raanan
Doviner, Victoria
Rubinstein, Ariel M.
Ishai-Michaeli, Rivka
Atzmon, Ruth
Sherman, Yoav
Meirovitz, Amichay
Peretz, Tamar
Vlodavsky, Israel
Elkin, Michael
Source :: Journal of Clinical Investigation. May 1, 2011, Vol. 121 Issue 5, p1709, 13 p.
Publication Year :: 2011
Abstract: Ulcerative colitis (UC) is a chronic inflammatory bowel disease that is closely associated with colon cancer. Expression of the enzyme heparanase is clearly linked to colon carcinoma progression, but its [...]

Subjects :: Epithelium -- Physiological aspects -- Research
Ulcerative colitis -- Development and progression -- Research
Enzymes -- Physiological aspects -- Research
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