Mutations in 2 distinct genetic pathways result in cerebral cavernous malformations in mice

Authors :: Chan, Aubrey C.
Drakos, Stavros G.
Ruiz, Oscar E.
Smith, Alexandra C.H.
Gibson, Christopher C.
Ling, Jing
Passi, Samuel F.
Stratman, Amber N.
Sacharidou, Anastasia
Revelo, M. Patricia
Grossmann, Allie H.
Diakos, Nikolaos A.
Davis, George E.
Metzstein, Mark M.
Whitehead, Kevin J.
Li, Dean Y.
Source :: Journal of Clinical Investigation. May 1, 2011, Vol. 121 Issue 5, p1871, 11 p.
Publication Year :: 2011
Abstract: Cerebral cavernous malformations (CCMs) are a common type of vascular malformation in the brain that are a major cause of hemorrhagic stroke. This condition has been independently linked to 3 [...]

Subjects :: Gene mutations -- Health aspects -- Research
Brain diseases -- Risk factors -- Genetic aspects -- Research -- Care and treatment
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