Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter

Authors :: Baughman, Joshua M.
Perocchi, Fabiana
Girgis, Hany S.
Plovanich, Molly
Belcher-Timme, Casey A.
Sancak, Yasemin
Bao, X. Robert
Strittmatter, Laura
Goldberger, Olga
Bogorad, Roman L.
Koteliansky, Victor
Mootha, Vamsi K.
Source :: Nature. August 18, 2011, Vol. 476 Issue 7360, p341, 7 p.
Publication Year :: 2011
Abstract: Mitochondria from diverse organisms are capable of transporting large amounts of [Ca.sup.2+] via a ruthenium-red-sensitive, membranepotential-dependent mechanism called the uniporter (1-4). Although the uniporter's biophysical properties have been studied extensively, [...]

Subjects :: Calcium channels -- Physiological aspects -- Research
Cell membranes -- Physiological aspects -- Research
Mitochondrial DNA -- Physiological aspects -- Research
Environmental issues
Science and technology
Zoology and wildlife conservation

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