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IgG Responses to tissue-associated antigens as biomarkers of immunological treatment efficacy
- Source :
- Journal of Biomedicine and Biotechnology. Annual 2011
- Publication Year :
- 2011
-
Abstract
- 1. Introduction Over the last two decades many new immunotherapy approaches to the treatment of cancer have entered clinical development due to the increased understanding of the mechanisms of antigen [...]<br />We previously demonstrated that IgG responses to a panel of 126 prostate tissue-associated antigens are common in patients with prostate cancer. In the current report we questioned whether changes in IgG responses to this panel might be used as a measure of immune response, and potentially antigen spread, following prostate cancer-directed immune-active therapies. Sera were obtained from prostate cancer patients prior to and three months following treatment with androgen deprivation therapy (n = 34), apoxviral vaccine (n = 31), and a DNA vaccine (n = 21). Changes in IgG responses to individual antigens were identified by phage immunoblot. Patterns of IgG recognition following three months of treatment were evaluated using a machine-learned Bayesian Belief Network (ML-BBN). We found that different antigens were recognized following androgen deprivation compared with vaccine therapies. While the number of clinical responders was low in the vaccine-treated populations, we demonstrate that ML-BBN can be used to develop potentially predictive models.
Details
- Language :
- English
- ISSN :
- 11107243
- Database :
- Gale General OneFile
- Journal :
- Journal of Biomedicine and Biotechnology
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.266629986
- Full Text :
- https://doi.org/10.1155/2011/454861