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Different patterns of peripheral migration by memory [CD4.sup.+] and [CD8.sup.+] T cells
- Source :
- Nature. September 8, 2011, Vol. 477 Issue 7363, p216, 6 p.
- Publication Year :
- 2011
-
Abstract
- Infections localized to peripheral tissues such as the skin result in the priming of T-cell responses that act to control pathogens. Activated T cells undergo migrational imprinting within the draining lymph nodes (1), resulting in memory T cells that provide local and systemic protection (2). Combinations of migrating and resident memory T cells have been implicated in long-term peripheral immunity, especially at the surfaces that form pathogen entry points into the body (3). However, T-cell immunity consists of separate [CD4.sup.+] helper T cells and [CD8.sup.+] killer T cells, with distinct effector and memory programming requirements (4). Whether these subsets also differ in their ability to form a migrating pool involved in peripheral immunosurveillance or a separate resident population responsible for local infection control has not been explored. Here, using mice, we show key differences in the migration and tissue localization of memory [CD4.sup.+] and [CD8.sup.+] T cells following infection of the skin by herpes simplex virus. On resolution of infection, the skin contained two distinct virus-specific memory subsets; a slow-moving population of sequestered [CD8.sup.+] T cells that were resident in the epidermis and confined largely to the original site of infection, and a dynamic population of [CD4.sup.+] T cells that trafficked rapidly through the dermis as part of a wider recirculation pattern. Unique homing-molecule expression by recirculating [CD4.sup.+] T effector-memory cells mirrored their preferential skin-migratory capacity. Overall, these results identify a complexity in memory T-cell migration, illuminating previously unappreciated differences between the [CD4.sup.+] and [CD8.sup.+] subsets.<br />Intravital microscopy has provided novel insights into the migration of naive and effector T cells in lymphoid and non-lymphoid compartments, although there has been no concurrent investigation of [CD4.sup.+] and [...]
- Subjects :
- T cells -- Health aspects -- Physiological aspects -- Research
Viral antibodies -- Health aspects -- Research
Infection -- Health aspects -- Care and treatment -- Research
Antibodies -- Health aspects -- Research
Environmental issues
Science and technology
Zoology and wildlife conservation
Subjects
Details
- Language :
- English
- ISSN :
- 00280836
- Volume :
- 477
- Issue :
- 7363
- Database :
- Gale General OneFile
- Journal :
- Nature
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.267708116
- Full Text :
- https://doi.org/10.1038/nature10339