A FOXO3-IRF7 gene regulatory circuit limits inflammatory sequelae of antiviral responses

Authors :: Litvak, Vladimir
Ratushny, Alexander V.
Lampano, Aaron E.
Schmitz, Frank
Huang, Albert C.
Raman, Ayush
Rust, Alistair G.
Bergthaler, Andreas
Aitchison, John D.
Aderem, Alan
Source :: Nature. October 18, 2012, Vol. 490 Issue 7420, p421, 7 p.
Publication Year :: 2012
Abstract: Antiviral responses must be tightly regulated to defend rapidly against infection while minimizing inflammatory damage. Type 1 interferons (IFN-I) are crucial mediators of antiviral responses (1) and their transcription is [...]

Subjects :: Interferon -- Physiological aspects -- Research
Genes -- Physiological aspects -- Research
Biological response modifiers -- Physiological aspects -- Research
Environmental issues
Science and technology
Zoology and wildlife conservation

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