Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence

Authors :: Jiang, Peng
Du, Wenjing
Mancuso, Anthony
Wellen, Kathryn E.
Yang, Xiaolu
Source :: Nature. January 31, 2013, Vol. 493 Issue 7434, p689, 7 p.
Publication Year :: 2013
Abstract: Cellular senescence both protects multicellular organisms from cancer and contributes to their ageing (1). The pre-eminent tumour suppressor p53 has an important role in the induction and maintenance of senescence, [...]

Subjects :: Cells -- Aging
Tumor suppressor genes -- Physiological aspects
Cell metabolism -- Research
Malate dehydrogenase -- Physiological aspects
Environmental issues
Science and technology
Zoology and wildlife conservation

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