Thymus-derived regulatory T cells contribute to tolerance to commensal microbiota

Authors :: Cebula, Anna
Seweryn, Michal
Rempala, Grzegorz A.
Pabla, Simarjot Singh
McIndoe, Richard A.
Denning, Timothy L.
Bry, Lynn
Kraj, Piotr
Kisielow, Pawel
Ignatowicz, Leszek
Source :: Nature. May 9, 2013, Vol. 497 Issue 7448, p258, 7 p.
Publication Year :: 2013
Abstract: Peripheral mechanisms preventing autoimmunity and maintaining tolerance to commensal microbiota involve [CD4.sup.+] [Foxp3.sup.+] regulatory T ([T.sub.reg]) cells (1,2) generated in the thymus or extrathymically by induction of naive [CD4.sup.+] [Foxp3.sup.-] [...]

Subjects :: T cells -- Research
Microbiota (Symbiotic organisms)
Immunopathology -- Research
Environmental issues
Science and technology
Zoology and wildlife conservation

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