Longitudinal relations between obesity and hypertension following pediatric renal transplantation

Obesity and hypertension frequently complicate renal transplantation (RTxp). The objective was to assess relations among obesity, hypertension, and glucocorticoids in pediatric RTxp recipients. A retrospective cohort study was carried out in 141 RTxp recipients, 2-21 years of age, with ≥ 12 months of follow-up. Body mass index Z-score (BMI-Z), systolic and diastolic blood pressure Z-scores (SBP-Z and DBP-Z), and medications at 1, 3, 6, and 12 months and annually thereafter were recorded. Quasi-least squares regression analysis was used. The prevalence of obesity (BMI >95th percentile) increased from 13% at baseline to >30% from 3 months onward. Greater glucocorticoid exposure (mg/kg/day) was associated with greater increases in BMI-Z (p Keywords Obesity * Hypertension * Renal transplant * Children * Glucocorticoid
Introduction Recent studies have established that the majority of young adults with a history of childhood-onset end-stage renal disease (ESRD) suffered significant cardiovascular morbidity and mortality. The risks of coronary [...]