Incidence of and risk factors for postoperative nausea and vomiting at a Japanese cancer center: first large-scale study in Japan

Purpose The first purpose of this study was to determine the incidence of postoperative nausea and/or vomiting (PONV) 0-48 h after anesthesia at a Japanese cancer center. The second purpose of this study was to collect information on PONV risk factors, independently, in the categories of patient-related, anesthesia-related, and surgery-related factors. Methods The frequency of nausea and vomiting was prospectively investigated from 0 to 48 h after anesthesia in 1645 patients (11-94 years of age) at a single medical institution. The occurrence of nausea and vomiting and the use of antiemetics were recorded up to 48 h after anesthesia. Patient-related, anesthesia-related, and surgery-related factors were also recorded and submitted to multiple logistic regression analysis to determine the relationship of these factors to nausea and vomiting. Results The incidences of nausea and vomiting from 0 to 24 h after anesthesia were 40 and 22 %, respectively. The incidences 24--48 h after anesthesia were 10 and 3 %, respectively. Female sex, previous history of PONV, prolonged anesthesia, and remifentanil use during surgery were identified as risk factors for both nausea and vomiting. The use of a volatile anesthetic, use of fentanyl during surgery, postoperative use of opioids, nonsmoking status, and drinking alcohol on 4 or fewer days per week were identified as risk factors for nausea alone. Conclusion The incidence of and risk factors for PONV at a Japanese cancer center according to this study are comparable to those reported elsewhere. Keywords Postoperative nausea and vomiting * PONV * Prospective study * Risk factors * Japan
Introduction Postoperative nausea and/or vomiting (PONV) is a significant postoperative complication that has been repeatedly investigated in surveys of incidence [1-4]. Many studies have sought to determine risk factors for [...]