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Sprouty2, PTEN, and PP2A interact to regulate prostate cancer progression

Authors :
Patel, Rachana
Gao, Meiling
Ahmad, Imran
Fleming, Janis
Singh, Lukram B.
Rai, Taranjit Singh
McKie, Arthur B.
Seywright, Morag
Barnetson, Robert J.
Edwards, Joanne
Sansom, Owen J.
Leung, Hing Y.
Source :
Journal of Clinical Investigation. March 1, 2013, Vol. 123 Issue 3, p1157, 19 p.
Publication Year :
2013

Abstract

Concurrent activation of RAS/ERK and PI3K/AKT pathways is implicated in prostate cancer progression. The negative regulators of these pathways, including sprouty2 (SPRY2), protein phosphatase 2A (PP2A), and phosphatase and tensin [...]

Subjects

Subjects :
Prostate cancer -- Development and progression -- Genetic aspects -- Research
Tumor suppressor genes -- Physiological aspects -- Research
Cellular signal transduction -- Physiological aspects -- Genetic aspects -- Research
Health care industry

Details

Language :
English
ISSN :
00219738
Volume :
123
Issue :
3
Database :
Gale General OneFile
Journal :
Journal of Clinical Investigation
Publication Type :
Academic Journal
Accession number :
edsgcl.341937302
Full Text :
https://doi.org/10.1172/JCI63672
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