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Acylglycerol kinase augments JAK2/STAT3 signaling in esophageal squamous cells

Authors :
Chen, Xiuting
Ying, Zhe
Lin, Xi
Lin, Huanxin
Wu, Jueheng
Li, Mengfeng
Song, Libing
Source :
Journal of Clinical Investigation. June 1, 2013, Vol. 123 Issue 6, p2576, 14 p.
Publication Year :
2013

Abstract

JAK2 activity is tightly controlled through a self-inhibitory effect via its JAK homology domain 2 (JH2), which restricts the strength and duration of JAK2/STAT3 signaling under physiological conditions. Although multiple [...]

Details

Language :
English
ISSN :
00219738
Volume :
123
Issue :
6
Database :
Gale General OneFile
Journal :
Journal of Clinical Investigation
Publication Type :
Academic Journal
Accession number :
edsgcl.341937446
Full Text :
https://doi.org/10.1172/JCI68143