Rare variants in single-minded 1 (SIM1) are associated with severe obesity

Authors :: Ramachandrappa, Shwetha
Raimondo, Anne
Cali, Anna M.G.
Keogh, Julia M.
Henning, Elana
Saeed, Sadia
Thompson, Amanda
Garg, Sumedha
Bochukova, Elena G.
Brage, Soren
Trowse, Victoria
Wheeler, Eleanor
Sullivan, Adrienne E.
Dattani, Mehul
Clayton, Peter E.
Datta, Vippan
Bruning, John B.
Wareham, Nick J.
O'Rahilly, Stephen
Peet, Daniel J.
Barroso, Ines
Whitelaw, Murray L.
Farooqi, I. Sadaf
Source :: Journal of Clinical Investigation. July 1, 2013, Vol. 123 Issue 7, p3042, 9 p.
Publication Year :: 2013
Abstract: Single-minded 1 (SIM1) is a basic helix-loop-helix transcription factor involved in the development and function of the paraventricular nucleus of the hypothalamus. Obesity has been reported in Sim1 haploinsufficient mice [...]

Subjects :: Physiological aspects
Genetic aspects
Research
Obesity -- Genetic aspects
Genetic research
Transcription (Genetics) -- Research
Hypothalamus -- Genetic aspects -- Physiological aspects
Genetic transcription -- Research

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