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Whole body correction of mucopolysaccharidosis IIIA by intracerebrospinal fluid gene therapy

Authors :
Haurigot, Virginia
Marco, Sara
Ribera, Albert
Garcia, Miguel
Ruzo, Albert
Villacampa, Pilar
Ayuso, Eduard
Anor, Sonia
Andaluz, Anna
Pineda, Mercedes
Garcia-Fructuoso, Gemma
Molas, Maria
Maggioni, Luca
Munoz, Sergio
Motas, Sandra
Ruberte, Jesus
Mingozzi, Federico
Pumarola, Marti
Bosch, Fatima
Source :
Journal of Clinical Investigation. August 1, 2013, Vol. 123 Issue 8, p3254, 18 p.
Publication Year :
2013

Abstract

For most lysosomal storage diseases (LSDs) affecting the CNS, there is currently no cure. The BBB, which limits the bioavailability of drugs administered systemically, and the short half-life of lysosomal [...]

Details

Language :
English
ISSN :
00219738
Volume :
123
Issue :
8
Database :
Gale General OneFile
Journal :
Journal of Clinical Investigation
Publication Type :
Academic Journal
Accession number :
edsgcl.341937521
Full Text :
https://doi.org/10.1172/JCI66778