False-positive ethyl glucuronide immunoassay screening associated with chloral hydrate medication as confirmed by LC-MS/MS and self-medication

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.forsciint.2008.10.022 Byline: Torsten Arndt (a), Birgit Gierten (a), Brunhilde Gussregen (a), Annika Werle (a), Joachim Gruner (b) Keywords: Alcohol; Chloral hydrate; Ethyl glucuronide; False-positive; Enzyme immunoassay; LC-MS Abbreviations: EtG, ethyl glucuronide; EtS, ethyl sulfate Abstract: Urine-ethyl glucuronide (EtG) concentrations are considered as a specific marker of recent alcohol consumption. We describe false-positive EtG screening results by the DRI.sup.[R] ethyl glucuronide enzyme immunoassay caused by chloral hydrate intake. Author Affiliation: (a) Bioscientia, Institut fur Medizinische Diagnostik GmbH, D-55218 Ingelheim, Germany (b) Private Practice, Frankfurt, Germany Article History: Received 28 August 2008; Revised 27 October 2008; Accepted 30 October 2008