Body mass index and annual estimated GFR decline in Chinese adults with normal renal function

BACKGROUND/OBJECTIVES: The objective of this study was to examine the association between body mass index (BMI) and the annual estimated glomerular filtration rate (eGFR) decline in a rural lean Chinese cohort. SUBJECTS/METHODS: A total of 2696 subjects with an eGFR [greater than or equal to] 60 ml/min per 1.73 [m.sup.2] were followed up for 7 years. Our primary outcome was annual eGFR decline, calculated as (eGFR at baseline--eGFR at revisit)/years of follow-up. RESULTS: During the 7-year follow-up, the mean (s.d.) of annual eGFR decline was 1.7 (1.9) ml/min per 1.73 [m.sup.2] per year. Compared with subjects with normal weight (BMI 19-22.9 kg/[m.sup.2]), overweight subjects (BMI 23-26.9 kg/[m.sup.2]) had a more rapid annual eGFR decline (β, 0.33;95% confidence interval (0.18-0.47) ml/min per 1.73 [m.sup.2] per year), whereas no significant difference was found when comparing the underweight ( CONCLUSIONS: Our results suggested a nonlinear S-shaped association between BMI and annual eGFR decline among Chinese adults with normal renal function. European Journal of Clinical Nutrition (2015) 69, 922-926; doi:10.1038/ejcn.2014.221; published online 29 October 2014
INTRODUCTION Chronic kidney disease (CKD) is now recognized as a worldwide public health problem. (1) A recent national cross-sectional survey (2) showed that the overall prevalence of CKD in adult [...]