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Homogeneous Subgroups of Young Children with Autism Improve Phenotypic Characterization in the Study to Explore Early Development
- Source :
- Journal of Autism and Developmental Disorders. November, 2017, Vol. 47 Issue 11, p3634, 12 p.
- Publication Year :
- 2017
-
Abstract
- The objective of this study was to identify homogenous classes of young children with autism spectrum disorder (ASD) to improve phenotypic characterization. Children were enrolled in the Study to Explore Early Development between 2 and 5 years of age. 707 children were classified with ASD after a comprehensive evaluation with strict diagnostic algorithms. Four classes of children with ASD were identified from latent class analysis: mild language delay with cognitive rigidity, mild language and motor delay with dysregulation, general developmental delay, and significant developmental delay with repetitive motor behaviors. We conclude that a four-class phenotypic model of children with ASD best describes our data and improves phenotypic characterization of young children with ASD. Implications for screening, diagnosis, and research are discussed.<br />Author(s): Lisa D. Wiggins [sup.1] , Lin H. Tian [sup.1] , Susan E. Levy [sup.2] , Catherine Rice [sup.3] , Li-Ching Lee [sup.4] , Laura Schieve [sup.1] , Juhi Pandey [...]
- Subjects :
- Health
Subjects
Details
- Language :
- English
- ISSN :
- 01623257
- Volume :
- 47
- Issue :
- 11
- Database :
- Gale General OneFile
- Journal :
- Journal of Autism and Developmental Disorders
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.508895173
- Full Text :
- https://doi.org/10.1007/s10803-017-3280-4