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Prenatal and Postnatal PCB-153 and p,p'-DDE Exposures and Behavior Scores at 5-9 Years of Age among Children in Greenland and Ukraine
- Source :
- Environmental Health Perspectives. October, 2017, Vol. 125 Issue 10, p107002, -107000 p.
- Publication Year :
- 2017
-
Abstract
- Background: Studies have reported some evidence of adverse effects of organochlorine exposures on child development, but the results have been inconsistent, and few studies have evaluated associations with child behavior. Objective: We investigated the association between prenatal and early-life exposures to 2,2',4,4',5,5' -hexachlorobiphenyl (PCB-153) and 1,1dichloro-2,2-bis(p-chlorophenyl)-ethylene (p,p'-DDE) and behaviors in children between 5 and 9 y of age. Methods: In the Biopersistent organochlorines in diet and human fertility: Epidemiologic studies of time to pregnancy and semen quality in Inuit and European populations (INUENDO) cohort, consisting of mother-child pairs from Greenland and Ukraine (n = 1,018), maternal serum PCB-153 and p,p'-DDE concentrations were measured during pregnancy, and cumulative postnatal exposures during the first 12 months after delivery were estimated using a pharmacokinetic model. Parents completed the Strengths and Difficulties Questionnaire (SDQ), and children's behaviors were dichotomized as abnormal (high) versus normal/borderline for five SDQ subscales and the total difficulties score. Results: The total difficulties score, an overall measure of abnormal behavior, was not clearly associated with pre- or postnatal exposures to PCB-153 or to p,p'-DDE. However, pooled adjusted odds ratios (ORs) for high conduct problem scores with a doubling of exposure were 1.19 (95% CI: 0.99, 1.42) and 1.16 (95% CI: 0.96, 1.41) for pre- and postnatal PCB-153, respectively, and 1.25 (95% CI: 1.04, 1.51) and 1.24 (95% CI: 1.01, 1.51) for preand postnatal p,p'-DDE, respectively. Corresponding ORs for high hyperactivity scores were 1.24 (95% CI: 0.94, 1.62) and 1.08 (95% CI: 0.81, 1.45) for pre- and postnatal PCB-153, respectively, and 1.43 (95% CI: 1.06, 1.92) and 1.27 (95% CI: 0.93, 1.73) for pre- and postnatal-p,p'-DDE, respectively. Conclusion: Prenatal and early postnatal exposures to p,p'-DDE and PCB-153 were associated with a higher prevalence of abnormal scores for conduct and hyperactivity at 5-9 y of age in our study population. These findings provide further support for the importance of minimizing organochlorine exposures to young children and to women of childbearing age. https://doi.org/10.1289/EHP553<br />Introduction Polychlorinated biphenyls (PCBs) have been widely used in, for example, hydraulic equipment, dyes, plasticizers, capacitors, transformers and flame retardants. Dichlorodiphenyltrichloroethane (DDT) has been used primarily as a pesticide and [...]
Details
- Language :
- English
- ISSN :
- 00916765
- Volume :
- 125
- Issue :
- 10
- Database :
- Gale General OneFile
- Journal :
- Environmental Health Perspectives
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.516634239
- Full Text :
- https://doi.org/10.1289/EHP553