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Influenza-specific lung-resident memory T cells are proliferative and polyfunctional and maintain diverse TCR profiles
Influenza-specific lung-resident memory T cells are proliferative and polyfunctional and maintain diverse TCR profiles
- Source :
- Journal of Clinical Investigation. February, 2018, Vol. 128 Issue 2, p721, 13 p.
- Publication Year :
- 2018
-
Abstract
- The human lung harbors a large population of resident memory T cells (Trm cells). These cells are perfectly positioned to mediate rapid protection against respiratory pathogens such as influenza virus, a highly contagious respiratory pathogen that continues to be a major public health burden. Animal models show that influenza-specific lung [CD8.sup.+] Trm cells are indispensable for crossprotection against pulmonary infection with different influenza virus strains. However, it is not known whether influenza-specific [CD8.sup.+] Trm cells present within the human lung have the same critical role in modulating the course of the disease. Here, we showed that human lung contains a population of [CD8.sup.+] Trm cells that are highly proliferative and have polyfunctional progeny. We observed that different influenza virus-specific [CD8.sup.+] T cell specificities differentiated into Trm cells with varying efficiencies and that the size of the influenza-specific [CD8.sup.+] T cell population persisting in the lung directly correlated with the efficiency of differentiation into Trm cells. To our knowledge, we provide the first ex vivo dissection of paired T cell receptor (TCR) repertoires of human influenza-specific [CD8.sup.+] Trm cells. Our data reveal diverse TCR profiles within the human lung Trm cells and a high degree of clonal sharing with other [CD8.sup.+] T cell populations, a feature important for effective T cell function and protection against the generation of viral-escape mutants.<br />Introduction Influenza A viruses cause substantial morbidity and mortality worldwide. Vaccination is considered to be the best way to prevent human influenza disease. Current antibody-based vaccines are highly effective in [...]
Details
- Language :
- English
- ISSN :
- 00219738
- Volume :
- 128
- Issue :
- 2
- Database :
- Gale General OneFile
- Journal :
- Journal of Clinical Investigation
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.526315471
- Full Text :
- https://doi.org/10.1172/JCI96957