Fully hydrogenated calixarene derivatives: calix(4)cyclohexanone and calix(4)cyclohexanol

The stereoselective synthesis of fully hydrogenated calixarene analogues was described. Saturated (1(n))-metacyclophane derivatives incorporating in the macrocycle cyclohexanone or cyclohexanol rings have the capability to act as host molecules and as potential synthetic intermediates for the synthesis of a novel class of calixarenes and host molecules. The rotational barrier of the product RsS SsR RsS SsR was determined using the saturation transfer method.