Mammalian Grb2 regulates multiple steps in embryonic development and malignant transformation

A study was undertaken to investigate the biological activity of the mammalian Grb2, a subset of the SH2 domain-containing proteins of protein-tyrosine kinases, to relate it to the genetic analysis of an SH2/SH3 adaptor. The mammalian Grb2 was believed to bind phosphoproteins, docking proteins and cytoplasmic tyrosine kinases. Results revealed that Grb2 manifested multiple activities in normal and oncogenic signaling pathways. It was suggested that the Grb2 signaling pathway regulated cell differentiation in the early embryonic development.