Congenital chloride diarrhea

Congenital chloride diarrhea is a recessively inherited disorder associated with the intestinal electrolyte absorption involving Cl-/HCO-/3 exchange. Caused by mutations in a chromosome 7 gene, the disease has been reported all around the world. The CLD gene supports a transmembrane protein related to the sulfate transporter family supporting three known members in human. Members of the gene family can also effectively transport other anions.