Cholecystokinin and serotonin receptors in the regulation of fat-induced satiety in rats

A study was conducted to determine the relationship between cholecystokinin (CCK) and serotonin (5-HT) in fat-induced satiety in rats. Selective receptor antagonists were used in the study to elucidate the roles of the two chemical modulators in fat-induced satiety. The antagonists Devazepide and Tropisetron were found in combination to completely block the satiating effects of the 80% fat infusate on all feeding variables that were measured. The results suggest that both endogenous 5-HT and CCK play a role in the satiety response to fat in the intestine.