Evidence for a rare prostate cancer-susceptibility locus at chromosome 1p36

A potential hereditary prostate cancer (PC) susceptibility locus has been shown to be on chromosome 1p36. Data from a genomic screen in 70 families with high risk for PC was combined with data from candidate-region mapping in the families and another 71 families. A significant fraction of the families with a high risk for PC and a family member with brain cancer (BC) have linkage at the 1p36 region. Cases of primary brain cancer often are seen in higher number in some families with high PC risk. Loss of heterozygosity at 1p36 is often seen in BC.