Akt promotes cell survival by phosphorylating and inhibiting a forkhead transcription factor

Authors :: Brunet, Anne
Bonni, Azad
Zigmond, Michael J.
Lin, Michael Z.
Juo, Peter
Hu, Linda S.
Anderson, Michael J.
Arden, Karen C.
Blenis, John
Greenberg, Michael E.
Source :: Cell. March 19, 1999, Vol. 96 Issue 6, p857, 1 p.
Publication Year :: 1999
Abstract: Previous studies have established that the serine/threonine kinase Akt has the capacity to inactivate the apoptotic process. Aside from this, a recent study found that Akt is also involved with the regulation of FKHRL1 which is a member of the Forkhead family of transcription factors. Serine/threonine kinase Akt is observed to phosphorylate FKHRL1 to bind it with 14-3-3 proteins, thus, keep it within the cytoplasm.

Subjects :: Cell death -- Research
Protein kinases -- Research
Cellular control mechanisms -- Research
Phosphorylation -- Research
Biological sciences

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