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Impaired Survival of Differentiating [Beta] Cells but No Insulin Secretory Defects Result from Ablation of IRS-2

Authors :
BONNER-WEIR, SUSAN
WITHERS, DOMINIC J
WEIR, GORDON C
JONAS, JEAN-CHRISTOPH
Source :
Diabetes. May, 1999, Vol. 48 Issue 5, SA3
Publication Year :
1999

Abstract

IRS-2 null mice (KO) have been shown to have severe insulin resistance and markedly reduced beta and non beta cell mass that result in rapid progression to diabetes. At both [...]

Subjects

Subjects :
Diabetes -- Research
Health

Details

ISSN :
00121797
Volume :
48
Issue :
5
Database :
Gale General OneFile
Journal :
Diabetes
Publication Type :
Periodical
Accession number :
edsgcl.54776017