Novel locus for autosomal dominant hereditary spastic paraplegia, on chromosome 8q

Autosomal dominant hereditary spastic paraplegia (HSP) has been shown, through analysis of a Caucasian kindred, to have a novel locus on chromosome 8q23-24. The locus takes in 6.2 cM between D8S1804 and D8S1774, and several potential candidate genes exist. Genetic loci exist on chromosomes 2p, 14q and 15q, but those loci are not a fit in 45% of autosomal dominant HSP kindreds.